InVivoSIM anti-human amyloid beta (Donanemab Biosimilar) clone: Donanemab (Catalog #SIM0048)
InVivoSIM 抗人類淀粉樣 β (Donanemab 生物仿制藥)抗 體,克?。篋onanemab(目錄號 #SIM0048)
Key features(主要特點):
1. Donanemab biosimilar is a humanized IgG1κ antibody against human amyloid-β protein precursor (APP).
2. Specifically reacts with abeta 42 (Aβ42) that drives the pathogenesis of Alzheimer’s disease (AD).
3. Donanemab biosimilars impede the progression of AD by clearing plaques through microglialmediated phagocytosis in mice without causing microhemorrhages.
4. Studies involving Alzheimer's disease and Down syndrome experimental models use the donanemab biosimilar
1. Donanemab 生物仿制藥是一種針 對人類淀粉樣 β 蛋白前體(APP) 的重組人源化 IgG1κ 抗體。
2. 特異性識別 Aβ42,Aβ42 驅動阿爾 茨海默癥(AD)的發病機制。
3. Donanemab 生物仿制藥通過小膠 質細胞介導的吞噬作用清除斑塊, 從而阻止 AD 的進展,同時不會引 起微出血。
4. Donanemab 生物仿制藥被用于阿 爾茨海默癥和唐氏綜合征實驗模型 的研究。
Application(應用): in vivo functional assays, in vitro functional assays, ELISA, Western blot
體內功能實驗、體外功能實驗、ELISA、 Western Blot
Research Area(研究領域): Neuroscience/神經科學
Related targets(相關靶點): Amyloid-beta, CD11b, TNF-α, IL-6, IL-3, VEGFR-2
淀粉樣 β、CD11b、TNF-α、IL-6、IL-3、 VEGFR-2
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